ICD code definitions

CPT® Code 79101: Radiopharmaceutical Therapy, Intravenous Administration

October 13, 2026
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3 min read
CPT® Code 79101

CPT® Code 79101 is used to report radiopharmaceutical therapy administered intravenously. The service involves the administration of a therapeutic radiopharmaceutical through an intravenous route as part of treatment for an appropriate medical condition.

Radiopharmaceutical therapy uses radioactive substances designed to deliver targeted radiation to specific tissues or disease sites. The treatment and monitoring process requires appropriate preparation, administration, and documentation.

Key Facts About CPT® 79101

  • Service type: Nuclear medicine therapeutic procedure
  • Procedure: Intravenous radiopharmaceutical therapy administration
  • Route: Intravenous
  • Purpose: Deliver therapeutic radiation through a radiopharmaceutical
  • Clinical setting: Nuclear medicine or radiation therapy
  • Provider type: Qualified physician or healthcare professional

Common clinical uses may include:

  • Treatment of certain thyroid conditions
  • Targeted radionuclide therapy
  • Treatment of selected malignancies
  • Other conditions for which intravenous therapeutic radiopharmaceuticals are clinically indicated

When to Use CPT® 79101

CPT 79101 may be reported when a therapeutic radiopharmaceutical is administered intravenously as part of an appropriate treatment plan.

Examples:

  • Administering an intravenous therapeutic radiopharmaceutical for a qualifying cancer treatment
  • Providing radionuclide therapy for a condition responsive to targeted radiation
  • Delivering a prescribed therapeutic radioactive agent under appropriate nuclear medicine protocols

The documentation should identify the clinical indication, radiopharmaceutical administered, route, and relevant treatment details.

Documentation Requirements

Documentation supporting CPT 79101 should include:

  • Patient identifiers and date of service
  • Diagnosis and clinical indication
  • Radiopharmaceutical or therapeutic agent administered
  • Dose or activity administered
  • Intravenous route and administration details
  • Treatment plan and clinical rationale
  • Relevant safety or monitoring information
  • Patient response and any complications
  • Follow-up or additional treatment plan

Detailed documentation helps support medical necessity and appropriate reporting of the therapeutic administration.

Reimbursement and Coding Considerations

  • CPT 79101 represents intravenous administration of a therapeutic radiopharmaceutical
  • The radiopharmaceutical itself may require separate reporting using the applicable code
  • Documentation should support the specific therapy and medical necessity
  • Radiation safety and facility requirements may apply depending on the treatment
  • Coverage and reimbursement vary by payer and treatment
  • Practices should verify payer-specific coding and billing requirements before submitting claims

Accurate documentation of the therapeutic agent, dose, route, and treatment indication is important for appropriate coding and reimbursement.

How OptiMantra Supports Treatment Documentation

OptiMantra helps practices document diagnoses, treatment procedures, medications, and follow-up care within the patient chart.

With OptiMantra, providers can:

  • Document radiopharmaceutical treatment and clinical indications within the patient chart
  • Record treatment details and administered therapies
  • Maintain relevant diagnoses and clinical findings
  • Use customizable chart templates for consistent documentation
  • Document patient response and follow-up plans
  • Maintain organized longitudinal patient records

Keeping treatment information and follow-up documentation within the patient chart helps support continuity of care throughout complex treatment plans.

Try OptiMantra for free here!

Disclaimer: CPT® codes are maintained by the American Medical Association. This guide is for informational purposes only and does not replace official coding guidelines or payer policies.

Jessica Castro
Jessica Castro

Jessica is a Massachusetts-based LPN with 13+ years of experience in patient care, healthcare technology, and education. As the Implementation and Customer Success Manager at OptiMantra, she helps providers optimize EMR solutions for better workflows and patient outcomes. With a Bachelor's in Community Health and a Master's in Healthcare Innovation in progress, she is passionate about leveraging technology to improve care delivery. Through her writing, she shares insights on healthcare best practices, EHR optimization, and patient advocacy to support providers in delivering exceptional care.