CPT® Code 82542 is used to report quantitative laboratory testing performed using column chromatography combined with mass spectrometry (LC/MS or GC/MS) with one stationary phase and one mobile phase, using non-radioactive methods. This advanced analytical technique allows precise measurement of specific analytes in biological specimens.
This code represents the analytical laboratory procedure itself, not specimen collection, interpretation, or evaluation and management services, which may be reported separately when appropriate.
Key Facts About CPT® 82542
- Service type: Advanced laboratory quantitative analysis
- Provider type: Physicians, laboratories, and qualified healthcare professionals
- Medical services included: Yes—quantitative analyte measurement
- Analytical method: Column chromatography with mass spectrometry
- Phases used: One stationary phase, one mobile phase
- Specimen type: Typically serum, plasma, urine, or other biological specimens
- Common clinical indications:
- Hormone and metabolite quantification
- Drug level monitoring
- Toxicology testing
- Nutrient or biomarker assessment
When to Use CPT® 82542
CPT 82542 is appropriate when:
- Quantitative analysis is performed using column chromatography and mass spectrometry
- The test requires one stationary phase and one mobile phase
- Non-radioactive analytical methods are used
- The service is not more accurately described by another specific CPT code
Examples:
- Quantitative hormone analysis using LC/MS
- Measurement of drug metabolites for therapeutic monitoring
- Precise biomarker quantification requiring mass spectrometry
Documentation Requirements
To support CPT 82542 billing, documentation should include:
- Patient identifiers and date of service
- Test ordered and analyte measured
- Specimen source
- Analytical method used (column chromatography/mass spectrometry)
- Quantitative results and units of measure
- Ordering provider information
Accurate documentation supports compliance, appropriate reimbursement, and clinical utility.
Reimbursement and Coding Considerations
- CPT 82542 reimbursement varies by payer and analyte tested
- Often used for specialty or reference laboratory testing
- Coverage may require medical necessity documentation and diagnosis linkage
- Frequency limits may apply depending on payer policies
- Should not be used when a more specific CPT code exists for the analyte
Always verify payer-specific laboratory billing guidelines prior to submission.
How OptiMantra Supports Advanced Laboratory Testing
OptiMantra’s integrated EMR and practice management system streamlines documentation and billing for CPT 82542:
With OptiMantra, providers can:
- Document analytes, methods, and results clearly
- Link lab findings to diagnoses and treatment plans
- Maintain longitudinal lab data for clinical monitoring
By centralizing lab workflows, OptiMantra helps practices improve efficiency, support compliance, and optimize reimbursement for advanced diagnostic testing.
Try OptiMantra for free here!
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