CPT® Code 82652 is used to report testing for 1,25-dihydroxy vitamin D, also known as calcitriol, the biologically active form of vitamin D. The test measures the concentration of 1,25-dihydroxy vitamin D in a patient's blood and may include measurement of the applicable fractions when performed.
Unlike the more commonly ordered 25-hydroxy vitamin D test, 1,25-dihydroxy vitamin D testing is generally used to evaluate specific conditions affecting vitamin D metabolism, calcium regulation, renal function, or abnormal vitamin D production.
Key Facts About CPT® 82652
- Service type: Laboratory test
- Test: 1,25-dihydroxy vitamin D (calcitriol)
- Specimen: Typically serum or plasma
- Purpose: Measure the biologically active form of vitamin D
- Testing: Includes fractions when performed
- Clinical use: Evaluation of disorders involving vitamin D metabolism and calcium regulation
Common clinical indications:
- Evaluation of abnormal calcium levels
- Certain disorders of vitamin D metabolism
- Renal disease affecting vitamin D activation
- Evaluation of suspected abnormalities in vitamin D production or regulation
- Certain granulomatous or other conditions associated with altered calcitriol production
When to Use CPT® 82652
CPT 82652 may be reported when a 1,25-dihydroxy vitamin D level is ordered and performed as part of an appropriate clinical evaluation.
Examples:
- Evaluating a patient with an unexplained abnormal calcium level
- Assessing vitamin D metabolism in the setting of certain renal disorders
- Investigating conditions that may cause abnormal production of active vitamin D
- Evaluating suspected disorders involving calcium, phosphorus, or vitamin D regulation
This test should be distinguished from 25-hydroxy vitamin D testing, which is commonly used to assess overall vitamin D status.
Documentation Requirements
Documentation supporting CPT 82652 should include:
- Patient identifiers and date of service
- Clinical indication for testing
- Relevant medical history
- Calcium, phosphorus, renal, or other pertinent laboratory findings
- 1,25-dihydroxy vitamin D test ordered or performed
- Laboratory result and applicable reference range
- Assessment or differential diagnosis
- Treatment, monitoring, or follow-up plan
Clear documentation helps establish the clinical reason for testing and supports medical necessity.
Reimbursement and Coding Considerations
- CPT 82652 represents 1,25-dihydroxy vitamin D testing
- The laboratory performing the test generally reports the applicable laboratory service
- Coverage and medical-necessity requirements vary by payer
- 1,25-dihydroxy vitamin D testing should not be substituted for 25-hydroxy vitamin D testing when the clinical objective is routine assessment of vitamin D status
- Documentation should support the reason the specific test was ordered
- Practices should verify payer-specific requirements before submitting claims
The clinical significance of the result should be interpreted alongside the patient's calcium balance, renal function, medical history, and other relevant laboratory findings.
How OptiMantra Supports Vitamin D Testing Documentation
OptiMantra helps practices organize laboratory orders, results, and related clinical documentation within the patient chart.
With OptiMantra, providers can:
- Document 1,25-dihydroxy vitamin D testing and its clinical indication
- Record laboratory results within the patient's medical record
- Keep vitamin D and related laboratory findings organized alongside medical history
- Link laboratory findings to diagnoses and treatment plans
- Document follow-up recommendations based on test results
- Maintain organized records for ongoing patient care and billing workflows
Keeping laboratory information connected to the patient's longitudinal record helps providers maintain comprehensive documentation around diagnostic testing.
Try OptiMantra for free here!
Disclaimer: CPT® codes are maintained by the American Medical Association. This guide is for informational purposes only and does not replace official coding guidelines or payer policies.
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