What is CPT® Code 96375?
CPT® code 96375 is used to report the therapeutic, prophylactic, or diagnostic intravenous (IV) administration of each additional drug or substance when given by IV push after the initial administration (typically reported with 96374). This code reflects the additional work and monitoring required when multiple IV medications are administered sequentially during a single encounter.
When to Use CPT® Code 96375
Use 96375 when:
- You administer an additional IV push of a different drug or substance (not a repeat of the same medication).
 - The IV push occurs after an initial administration (e.g., after a medication billed under 96374).
 - The injection is given at a different time or through the same IV access but requires distinct documentation of the additional service.
 - The provider or qualified healthcare professional must remain available to monitor the patient’s response and manage any potential adverse reactions.
 
Documentation Requirements
To bill 96375 appropriately, documentation should include:
- The name and dosage of each drug or substance administered
 - The route and timing of administration
 - Medical necessity for each medication
 - The sequence of administration (indicating which was first and which was subsequent)
 - Provider supervision and patient monitoring details
 
For compliance, ensure each additional IV push represents a separate and necessary therapeutic intervention — not merely a continuation or repeat of the same substance.
Billing Guidelines
- 96375 is an add-on code, meaning it must be reported in conjunction with a primary code, typically 96374 (initial IV push).
 - Do not report 96375 for a repeat administration of the same drug — instead, use 96376 for a subsequent push of the same medication.
 - Each distinct drug or substance administered by IV push after the initial can be billed once per encounter.
 - The service must be performed by qualified clinical staff under appropriate supervision.
 
Example
A patient receives IV ondansetron for nausea (initial administration, 96374), followed by IV ketorolac for pain relief (additional, 96375). Both medications are medically necessary, given through the same IV line but at separate times.
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With OptiMantra’s integrated charting and billing tools, documenting and coding procedures like 96375 becomes simple and error-free. Providers can log IV administrations directly within the encounter note, automatically capture time and drug details, and generate accurate superbills. This ensures complete, compliant documentation and faster reimbursement—helping your team focus less on coding complexities and more on patient care.
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