CPT® code 96366 is used to report each additional hour of an intravenous (IV) infusion of a therapeutic, prophylactic, or diagnostic substance or drug, administered after the first hour of infusion. This code is always add-on and must be reported in conjunction with the initial hour (typically coded as CPT 96365).
What is CPT 96366?
CPT 96366 applies when an IV infusion continues beyond the first 60 minutes. It is reported per additional hour and is only billable if each extra hour is a full 31 minutes or more.
This code is frequently used in infusion therapy for:
- Hydration
- Antibiotics
- Electrolytes
- Biologic agents
- Other non-chemotherapy treatments
Providers must ensure the start and stop times of the infusion are clearly documented, as accurate time tracking is required to bill this service.
CPT 96366 is not used for push injections, chemotherapy drugs, or hydration infusions unless specific conditions are met. It must always be reported with a primary code, such as CPT 96365.
When to report CPT code 96366
You may report 96366 when:
- An IV infusion of a non-chemotherapy therapeutic, prophylactic, or diagnostic agent lasts longer than one hour
- The initial hour has been reported with CPT 96365
- Additional full hours (31+ minutes) of infusion time are medically necessary and documented
- The infusion is sequential or concurrent, depending on administration details
Example: A patient is administered IV vancomycin. The first hour is billed using CPT 96365. The infusion continues for another 1 hour and 20 minutes. Because the second hour exceeds 31 minutes, the provider reports CPT 96366 once for the additional time.
Billing tips and documentation requirements
- Start and stop times must be clearly documented in the medical record
- CPT 96366 is an add-on code and cannot be billed alone
- If multiple substances are infused, sequence codes based on primary, secondary, or concurrent administration
- Report J-codes separately for the specific drug(s) used
- Modifier usage is not typically required unless bundling issues arise with E/M services
How OptiMantra Supports Infusion Therapy Documentation
For practices offering infusion services—whether in functional medicine, integrative care, or outpatient treatment settings—OptiMantra streamlines how you document and bill for codes like CPT 96366. The platform enables:
- Build custom templates that include fields for start/stop time tracking
- Create procedure-specific documentation workflows tailored to your practice
- Use linked superbills and inventory tools to ensure accurate billing for services and products
- Submit claims electronically and track reimbursement statuses in real time
By offering flexible documentation tools and integrated billing features, OptiMantra helps practices stay organized and efficient—even when handling time-sensitive procedures like infusion therapy.
Try OptiMantra for free here!
